P. cubensis is probably the most widely known of the psilocybin-containing mushrooms used for triggering psychedelic experiences after ingestion. Its major psychoactive compounds are Psilocybin, Psilosin, Baeocystin, Norbaeocystin, and Aeruginascin.

There are many different ways to ingest Psilocybe cubensis. Users may prefer to take them raw, freshly harvested, or dried and preserved. It is also possible to prepare culinary dishes such as pasta or tea with the mushrooms.

Upon ingestion, effects usually begin after approximately 20–60 minutes (depending on the method of ingestion and stomach contents) and may last from four to ten hours, depending on dosage and individual biochemistry. Visual distortions often occur, including walls that seem to breathe, a vivid enhancement of colors, and the animation of organic shapes.

The effects of high doses can be overwhelming depending on the particular phenotype of cubensis, grow method, and the individual.

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