Frustration: the feeling of being upset or annoyed, especially because of an inability to change or achieve something.
"Now this, bhikkhus, is the noble truth of the origin of suffering: it is this craving [taṇhā, "thirst"] which leads to re-becoming, accompanied by delight and lust, seeking delight here and there; that is, craving for sensual pleasures, craving for becoming, craving for disbecoming." - Dhammacakkappavattana Sutra